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Glycopeptide dendrimers, Part III—a review: Use of glycopeptide dendrimers in immunotherapy and diagnosis of cancer and viral diseases

Identifieur interne : 001322 ( Main/Exploration ); précédent : 001321; suivant : 001323

Glycopeptide dendrimers, Part III—a review: Use of glycopeptide dendrimers in immunotherapy and diagnosis of cancer and viral diseases

Auteurs : Petr Niederhafner [République tchèque] ; Milan Reiniš [République tchèque] ; Jaroslav Šebestík [République tchèque] ; Jan Ježek [République tchèque]

Source :

RBID : ISTEX:0E9802423ACEDED654B076627B0AF400FBC38155

English descriptors

Abstract

Glycopeptide dendrimers containing different types of tumor associated‐carbohydrate antigens (TN, TF, sialyl‐TN, sialyl‐TF, sialyl‐Lex, sialyl‐Lea etc.) were used in diagnosis and therapy of different sorts of cancer. These dendrimeric structures with incorporated T‐cell epitopes and adjuvants can be used as antitumor vaccines. Best results were obtained with multiantigenic vaccines, containing, e.g. five or six different TAAs. The topic of TAAs and their dendrimeric forms at molecular level are reviewed, including structure, syntheses, and biological activities. Use of glycopeptide dendrimers as antiviral vaccines against HIV and influenza is also described. Their syntheses, physico‐chemical properties, and biological activities are given with many examples. Copyright © 2008 European Peptide Society and John Wiley & Sons, Ltd.

Url:
DOI: 10.1002/psc.1011


Affiliations:


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Le document en format XML

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<div type="abstract" xml:lang="en">Glycopeptide dendrimers containing different types of tumor associated‐carbohydrate antigens (TN, TF, sialyl‐TN, sialyl‐TF, sialyl‐Lex, sialyl‐Lea etc.) were used in diagnosis and therapy of different sorts of cancer. These dendrimeric structures with incorporated T‐cell epitopes and adjuvants can be used as antitumor vaccines. Best results were obtained with multiantigenic vaccines, containing, e.g. five or six different TAAs. The topic of TAAs and their dendrimeric forms at molecular level are reviewed, including structure, syntheses, and biological activities. Use of glycopeptide dendrimers as antiviral vaccines against HIV and influenza is also described. Their syntheses, physico‐chemical properties, and biological activities are given with many examples. Copyright © 2008 European Peptide Society and John Wiley & Sons, Ltd.</div>
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